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Interactions between Tasigna oral and moderate-cyp3a4-inhibitors-ergotamine-derivatives

Interactions between Tasigna oral and moderate-cyp3a4-inhibitors-ergotamine-derivatives

Ergotamine Derivatives/Moderate CYP3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:


Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:


When these two medicines are taken together, your body may not process ergotamine derivatives properly.

What might happen:


Your blood levels of your ergotamine derivatives may increase and cause toxic effects.

What you should do about this interaction:


Let your healthcare professional (e.g. doctor or pharmacist) know that you are using these medicines together. Your doctor may not want you to take any ergotamine derivatives while you are taking your other medicine or may change the dose of your ergotamine derivative.If you experience chest pain; change in heartbeat; numbness and tingling of hands, feet, or face; pain in arms, legs, or lower back; itching; or other symptoms while taking both of these medicines, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:


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11.Franco A, Bourlard P, Massot C, Lecoeur J, Guidicelli H, Bessard G. Acute ergotism caused by dihydroergotamine-triacetyloleandomycin association. Nouv Presse Med 1978 Jan 21;7(3):205.

12.Vayssairat M, Fiessinger JN, Bequemin MH, Housset E. Dihydroergotamine and triacetyloleandomycin combination. Its role in iatrogenic necrosis of the fingers. Nouv Presse Med 1978 Jun 10;7(23):2077.

13.Boucharlat J, Franco A, Carpentier P, Charignon Y, Denis B, Hommel M. Ergotism in a psychiatric setting caused by combined dihydroergotamine- erythromycin propionate. Apropos of a case. Ann Med Psychol (Paris) 1980 Mar;138(3):292-6.

14.Neveux E, Lesgourgues B, Luton JP, Guilhaume B, Bertagna, Picard J. Acute ergotism caused by the interaction of erythromycin propionate and dihydroergotamine. Nouv Presse Med 1981 Sep 26;10(34):2830.

15.Couet W, Mathieu HP, Fourtillan JB. Effect of ponsinomycin on the pharmacokinetics of dihydroergotamine administered orally. Fundam Clin Pharmacol 1991;5(1):47-52.

16.Nelson MV, Berchou RC, Kareti D, LeWitt PA. Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine. Clin Pharmacol Ther 1990 Jun;47(6):694-7.

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18.Mortier E, Pouchot J, Vinceneux P, Lalande M. Ergotism related to interaction between nelfinavir and ergotamine. Am J Med 2001 May; 110(7):594.

19.Montero A, Giovannoni AG, Tvrde PL. Leg ischemia in a patient receiving ritonavir and ergotamine. Ann Intern Med 1999 Feb 16;130(4 Pt 1):329-30.

20.Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, del Nozal M, Lopez-Cortes LF. Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient. Antimicrob Agents Chemother 1997 May;41(5):1207.

21.Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D. Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir. Postgrad Med J 1999 Sep;75(887):546-7.

22.Liaudet L, Buclin T, Jaccard C, Eckert P. Drug points: severe ergotism associated with interaction between ritonavir and ergotamine. BMJ 1999 Mar 20;318(7186):771.

23.Pardo Rey C, Yebra M, Borrallo M, Vega A, Ramos A, Montero MC. Irreversible coma, ergotamine, and ritonavir. Clin Infect Dis 2003 Sep 1; 37(5):e72-3.

24.Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W. Cerebral ergotism under treatment with ergotamine and ritonavir. Neurology 2001 Aug 28;57(4):743-4.

25.Vila A, Mykietiuk A, Bonvehi P, Temporiti E, Uruena A, Herrera F. Clinical ergotism induced by ritonavir. Scand J Infect Dis 2001; 33(10):788-9.

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