From the Stanford University School of medicine, researchers published a report entitled " The ageing systemic milieu negatively regulates neurogenesis and cognitive function " article, found in the blood of a cytokine components can promote brain aging, this will help scientists better understand the mechanisms of aging related results published in the Journal Nature..As the body ages, the brain will become dull. Even in those immune to neurodegenerative diseases ( such as Alzheimer's disease ) people, few new neurons from brain cells to be created, and the already existing neurons also will gradually become weak.Before researchers to display to the older rats injected with young rats blood will stimulate the immune system in senile rats and muscle function. In this article, the researchers to clarify the phenomenon can also occur in the brain of blood brain barrier. Although a lot of blood in the limit of large molecules into the brain, but this layer boundaries are not in all places are sealed well, this will have the opportunity to make some mixture through. These boundaries in the brain cells are particularly seal is not good, suggesting that these neuronal precursors may have the opportunity and the circulatory system.The researchers analyzed three month old mice and roughly two-year-old mice nerve formation, then they use operation method to young and old mice mouse circulatory system together. It was found in mouse brain in the hippocampus ( A and memory formation in relation to the organization) inside the new cell from less than the 400 rose to nearly 1000, while the young mouse cells declined by nearly 1/4.
But with the younger mice compared, aged mice in the dentate gyrus with reduced pair of adrenocorticotropic hormone ( DCX ) immunoreactive nerve cell number, this means the reduction of neurogenesis, and in fear conditioning and rotating arm water maze ( RAWM ) example, shown in Lai Haima's learning ability damage.Next, the researchers using standardized multiplexed sandwich enzyme-linked immunosorbent assay, found including CC chemokine ligand 11 ( CCL11 ), 6 proteins, these proteins in aged mice by unpaired and young mice plasma have increased. They focus on the CCL11, it was found this chemokine levels in the elderly in the plasma and cerebral spinal fluid, as well as the old mouse plasma appeared to increase.The study analyses the aging secrets, the next step the researchers plan to scan hundreds of other factors, there is no other factors are also analyzed in the aging brain plays a decisive role.Leukemia Inhibitory Factor