Updated February 12, 2014.

Definition:

Street slang meaning to shoot up or smoke a mixture of cocaine and heroin; ecstasy mixed with ketamine; the simultaneous use of a stimulant with a depressant.

This term is one of more than 2,300 street terms that refer to specific drug types or drug activity compiled by the White House Office of National Drug Control Policy.

Also Known As: Belushi.

Examples: Years of speedballing began to take its toll on his health.