Increased Episodic Depression

• A pre-existing diagnosis of depression and long term use of lorazepam may cause the symptoms of depression to re-emerge or worsen.
  
  

Possible Respiratory Decline

• Long term use of lorazepam may cause an adverse reaction on respiratory processes, including a decline in the ability to breathe.
  
  

Lower Tolerance for Alcohol

• Long term and short term use of lorazepam lowers the body's tolerance to other medications and alcohol.
  
  

Possible Physical and Psychological Dependence

• Long term use can lead to both physical and psychological dependence.
  
  

Possible Toxic Psychosis

• Long term use of lorazepam can cause the body to be in a constant state of intoxication, resulting in toxic psychosis.
  
  

Possible Withdrawal Symptoms With Cessation

• Taking lorazepam for as short of a time as a week and then stopping abruptly can cause withdrawal symptoms such as irritability, confusion, insomnia and dizziness, among many other symptoms.