Conclusion
The injury severity score in the I/R + Ed group compared to the I/R group showed a significantly a lower rate both in GC and TA samples. While edaravone may have multiple effects, our data showed that pretreatment with edaravone protected muscle tissue from damage due to ischemia-reperfusion. We speculate that pretreatment of edaravone directly inhibits lipid peroxidation of myocytes by free radicals in skeletal muscles after I/R injury and indirectly protects myocytes from secondary damage due to edema, inflammatory infiltration and transduction of oxidative stress. Further studies are warranted to confirm the novel therapeutic potential edaravone may have for I/R injuries of skeletal muscle.