Conclusions
Products A and B have multiple neurosurgical applications. As an adjunct to standard hemostatic procedures, they facilitate rapid hemostasis and have bactericidal activity that extends to antibiotic-resistant organisms such as methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pneumonia, as well as Pseudomonas aeruginosa. Risks can be minimized with appropriate use, including product removal following hemostasis whenever possible, and removal at all times when the product is applied in, around, or in proximity to, foramina in bone, areas of bony confine, the spinal cord, and/or the optic nerve. Both products are effective in controlling venous oozing during approaches to the skull base where safe, precise, and rapid hemostasis is critical. The authors recommend the use of oxidized regenerated cellulose for interventions in the cerebrum for rapid hemostasis of capillary or post-resection ooze. Whether to help with manipulation of the aneurysmal dome or to aid in the rapid identification of the rupture point during an intraoperative rupture, the use of oxidized regenerated cellulose is not uncommon in practice and approach to cerebrovascular disease.